Abstract: It can fully use heterogeneous network resources, provide resource requirement for cloud computing platform, this paper designed an IPv4/IPv6 virtual machine migration transition framework based on tunnel technology, prefix management, address pool management and mobile IP.The framework application tradition IPv4/IPv6 transition technology and mobile IP technology for virtual machine migration in cloud computing.It uses the paper designed cloud computing control engine as a core and IPv4/IPv6 plug-in collaboration completion virtual machine migration.Experiment shows the framework can provides IPv4/IPv6 cloud computing service for client and support IPv4/IPv6 virtual machine seamless migration.The framework can be applied to construction cloud computing platform in the IPv4/IPv6 transition period.