Abstract: To solve the resource-constrained project scheduling problem (RCPSP) with activity splitting,an optimization method combined artificial bee colony algorithm with serial scheduling scheme for activity splitting is presented.In ABC algorithm the location of each food source represents priorities of activities,which can be transformed to a feasible schedule by serial scheduling scheme for activity splitting.In the iterative process the global optimal solution is updated according to the different behaviors of three type artificial bees.The actual calculation shows that the artificial bee colony algorithm is valid for resource-constrained and activity splitting project scheduling problem with fast convergence speed and high precision.