Abstract: In view of the traditional TCP control protocol in low efficiency in heterogeneous network,research of network cognitive based on immune and gray system theory is proposed.The research utilizes artificial immune system analysis parameters characteristics and the use of grey correlation to build the performance of the correlation between network parameters and the current network,through some data analysis to accurate and efficient cognition network.This research uses Transmission Control Protocol(TCPL) to finish simulation experiments.Simulation show: Under different background flow conditions,the algorithm can stabilize sending window,reduce congestion and improve throughput and transmission efficiency.