Abstract: Hybrid algorithm of invasive weed optimization and ant colony algorithm is applied to solve emergency vehicle configuration problem. A double-section weed can be decoded into one emergency plan. Sub route is optimized by ants, and good local information is got by weed population. Hybrid algorithm is used to optimize an emergency problem of one area with two objectives (time and cost). The results show algorithm haves an advantage in terms of different numbers of vehicles, and it's an effective tool to solve this kind of problem.