Abstract: To overcome the inter-cell interference from TDD wireless heterogeneous network,the simulation and analysis to Home NodeB's interference received from Marco NodeB and neighboring Home NodeB are applied,and the relationship between the coverage of uplink or downlink and the deployment density and location of Home NodeB is in this paper.The research above mentioned supports the significant foundation for setting and adjusting to configuration parameters,and it also provides the necessary reference data for self-configuration and self-optimization algorithm design of Home NodeB.