Abstract: In order to overcome premature convergence of particle swarm optimization and evolution of particles in the direction of the lack of good guidance to the problem,by the immune system and the inspired ideas of quantum computing,quantum technology and the use of immune mechanisms to the immunity applied to the quantum particle swarm algorithm,the immune quantum particle swarm optimization.Can guide the direction of particle evolution towards better,improve the convergence rate of the quantum particle swarm optimization ability and experimental results show that the simulation results show that the algorithm has better performance,solving the TSP problem in the convergence speed and searching capability have achieved better results.