Abstract: In the radiation environment, SRAM-based FPGA will be affected by single event upsets(SEU) resulting in errors in configuration frame, and the extent of each configuration frame affected varies. In order to improve the pertinence of the scrubbing, a key-degree-based multi-frequency scrubbing address generation algorithm is proposed and the hardware of the scrubber is implemented. According to the degree of each configuration frame affected by SEU, different scrubbing frequencies are implemented for different frames, and the generated scrubbing sequence is also analyzed.