Abstract: Evolutional self-repair is a new self-repair method for embryonics array besides row/column elimination and cell elimination. The evolution hardware theory can be used for the evolutional self-repair. But in evolve process, the solution space is large, and the function of every individual circuit should be evaluated, the computed amount is huge. A novel evolutional self-repair method based on function re-differentiation is proposed in this paper. Based on the circuit netlist composed of electronic cells, the target circuit is physical re-mapped on the embryonics array with faulty cells, and the circuit form with larger self-repair capacity is searched. The faulty cells' impact on embryonics array is analyzed in detail, and a mathematical model is built for the physical re-mapping, and the function re-differentiation based evolutional self-repair process is established. The proposed method does not require the evaluation of circuits' function, and the amount of computation is reduced, which make a foundation to achieve fast evolutional self-repair. Finally, the proposed method was validated through an experimental circuit simulation.