Abstract: Tailorable SOC design has the most streamlined structure and needs the least resources, which can achieve the best efficiency and satisfy various applications. Interface protocol of tailorable SOC is proposed, which is compatible to Wishbone interface protocol. It includes the overall structure,interface definition and the implementation of interface adapter. The advantages of interface protocol of tailorable SOC are reflected in compatibility with Wishbone, high versatility and low power dissipation. The interface protocol is beneficial to plug- and-play SOC system and can satisfy heterogeneous muti-module SOC's flexible configuration.